The main interest of the lab is studying gene circuits of immune cells involving differentiation, activation and regulation. We focus on exploring these cells and circuits mainly in the context of the tumor micro environment following stimulation, immunotherapies or cell-cell interactions.
We apply cutting-edge technologies including mouse tumor models, molecular biology, single cell RNAseq and other high-throughput genetic and genomic methods combined with advanced computational approaches to identify and functionally characterize genes that play an important role in immune cell circuits and their effect on tumor growth.
This approach, will enable in-depth studies of immune-cell signaling in the context of interaction with tumor-resident cell types and tumor microenvironment.
Moreover, this approach could be readily adapted to studying the effect of these genetic circuits in other settings, such as immune cells in organ-specific autoimmunity. These unique signaling signatures could become new ‘biomarkers’ and facilitate our understanding of both disease pathogenesis, diagnosis and treatment.